2. Neurological Disease

Neurological Disease

Neurological Disease

Related Products

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-10053B
    Maropitant citrate 862543-54-2 98%
    Maropitant citrate is an orally active NK1 receptor antagonist. Maropitant citrate prevents vomiting and inhibits ulcerative dermatitis.
    Maropitant citrate
  • HY-10053R
    Maropitant (Standard) 147116-67-4 98%
    Maropitant (Standard) is the analytical standard of Maropitant. This product is intended for research and analytical applications. Maropitant is a selective and orally active neurokinin (NK1) receptor antagonist. Maropitant acts by blocking the binding of substance P within the emetic center and the chemoreceptor trigger zone (CRTZ). Maropitant is highly effective in preventing vomiting.
    Maropitant (Standard)
  • HY-100642
    3-O-Methyltolcapone 134612-80-9 99.95%
    3-O-Methyltolcapone (Ro 40-7591) is a metabolite of Tolcapone (HY-17406). Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma.
    3-O-Methyltolcapone
  • HY-100840
    (S)-4C3HPG 85148-82-9 98%
    (S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice.
    (S)-4C3HPG
  • HY-100906
    1,1-Dimethyl-4-acetylpiperazinium iodide 75667-84-4 98%
    1,1-Dimethyl-4-acetylpiperazinium iodide is an agonist for nicotinic acetylcholine receptor (nAChR) that open ion channels and causes cell membrane depolarization.
    1,1-Dimethyl-4-acetylpiperazinium iodide
  • HY-10095R
    Olcegepant (Standard) 204697-65-4 98%
    Olcegepant (Standard) is the analytical standard of Olcegepant (HY-10095). This product is intended for research and analytical applications. Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP.
    Olcegepant (Standard)
  • HY-100990
    MMPX 78033-08-6 98%
    MMPX is a potent PDE1 inhibitor.
    MMPX
  • HY-101207
    NCS-382 520505-01-5 98%
    NCS-382 is a potent GABA receptor antagonist and also a GHBR receptor antagonist. NCS-382 has anticonvulsant and antisedative activity. NCS-382 is used in the related research of hereditary nervous system diseases.
    NCS-382
  • HY-10121R
    Asenapine (Standard) 65576-45-6 98%
    Asenapine (Standard) is the analytical standard of Asenapine. This product is intended for research and analytical applications. Asenapine (Org 5222), an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.
    Asenapine (Standard)
  • HY-101240
    Propranolol glycol 36112-95-5 99.30%
    Propranolol glycol is a metabolite of propranolol (HY-B0573B). Propranolol glycol shows instantaneous anticonvulsant activity.
    Propranolol glycol
  • HY-101321
    Immepip 151070-83-6 99.05%
    Immepip is a H3 agonist. Immepip can reduce cortical histamine release. Immepip can be used for the research of neurological diseases.
    Immepip
  • HY-10133R
    β-Secretase Inhibitor IV (Standard) 797035-11-1 98%
    β-Secretase Inhibitor IV (Standard) is the analytical standard of β-Secretase Inhibitor IV (HY-10133). This product is intended for research and analytical applications. β-Secretase Inhibitor IV is a potent, cell-active BACE-1 inhibitor with IC50s of 15.6 and 16.3nM under BACE-1 concentrations of 2 nM and 100 pM, respectively.
    β-Secretase Inhibitor IV (Standard)
  • HY-101344
    Cyanopindolol fumarate 69906-86-1 98%
    Cyanopindolol fumarate is a 5-HT receptor antagonist.
    Cyanopindolol fumarate
  • HY-101353
    LY 235959 137433-06-8 98%
    LY 235959 is a competitive N-methyl-D-aspartate (NMDA)-receptor antagonist. LY 235959 potentiates the anticonvulsant action of antiepileptics.
    LY 235959
  • HY-101553
    Triflubazam 22365-40-8 98%
    Triflubazam is an anti-anxiety agent. Triflubazam can be used for the research of sleep disorder.
    Triflubazam
  • HY-101573
    Bencianol 85443-48-7 98%
    Bencianol is a the semisynthetic flavinoid, with anti-spasmogenic activities.
    Bencianol
  • HY-101596
    Ethyl dirazepate 23980-14-5 98%
    Ethyl dirazepate is a agent which is a benzodiazepine derivative. It has anxiolytic and possibly other characteristic benzodiazepine properties.
    Ethyl dirazepate
  • HY-101600
    RPR104632 154106-92-0 98%
    RPR104632 is a specific antagonist of NMDA receptor, with potent neuroprotective properties.
    RPR104632
  • HY-101612
    SPD-473 citrate 161190-26-7 99.80%
    SPD-473 citrate is a serotonin/dopamine/norepinephrine reuptake inhibitior.
    SPD-473 citrate
  • HY-101616
    ABT-639 hydrochloride 1235560-31-2 98%
    ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker.
    ABT-639 hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity